Open AccessDevelopment of a murine animal model of depression for repeated dosing with human interferon alpha
Author(s) -
Nagesh Koregala Siddegowda,
Nisha Rao,
Chittaranjan Andrade
Publication year - 2011
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.86815
Subject(s) - behavioural despair test , motility , animal model , basal (medicine) , depression (economics) , open field , dosing , alpha (finance) , pharmacology , saline , medicine , biology , surgery , construct validity , genetics , macroeconomics , patient satisfaction , hippocampus , insulin , economics , antidepressant
Neuropsychiatric adverse effects of interferon (IFN) alpha are well known. There is little clinically relevant research on animal models of depression with recombinant human IFN alpha 2b (rhIFN-α2b).