Open AccessSevere neuropsychiatric presentation of Wilson′s disease
Author(s) -
Rahul T Chakor,
NS Santhosh
Publication year - 2011
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.82556
Subject(s) - penicillamine , ceruloplasmin , lorazepam , presentation (obstetrics) , medicine , wilson's disease , copper metabolism , disease , pediatrics , urinary system , psychiatry , surgery , copper , chemistry , organic chemistry
Wilson's disease (WD) is a relatively rare disease of copper metabolism. The diagnosis is often missed initially. The presentation is usually neurologic or hepatic, seen in 40% of patients. Psychiatric presentation of WD is reported in only 15% of patients. We present a 32-year-old patient with severe psychiatric manifestations. On examination, he had mild rest and postural tremors and a KF ring was seen. Serum ceruloplasmin was low and 24-hour urinary copper was elevated. The patient responded to penicillamine, lorazepam and quetiapine, and is being followed up.