Stevens-Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) overlap associated with carbamazepine use | Zendy

PN Suresh Kumar | Zendy; Biju Thomas | Zendy; Kishore R. Kumar | Zendy; Shibu Kumar | Zendy

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Stevens-Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) overlap associated with carbamazepine use

Author(s) -

PN Suresh Kumar,

Biju Thomas,

Kishore R. Kumar,

Shibu Kumar

Publication year - 2005

Publication title -

indian journal of psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.485

H-Index - 34

eISSN - 1998-3794

pISSN - 0019-5545

DOI - 10.4103/0019-5545.55961

Subject(s) - toxic epidermal necrolysis , carbamazepine , erythema multiforme , dermatology , exfoliative dermatitis , mania , medicine , mucocutaneous zone , rash , chlorpromazine , lamotrigine , erythema , lithium (medication) , bipolar disorder , psychiatry , epilepsy , pharmacology , disease

A benign pruritic rash occurs in 10%-15% of persons treated with carbamazepine. A small fraction of them may experience life-threatening dermatological syndromes such as exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The case of an 18-year-old female suffering from bipolar affective disorder (mania) who was being treated with carbamazepine, lithium, chlorpromazine and benzhexol is presented. After 10 days of treatment, she developed high-grade fever and mucocutaneous manifestations of SJS-TEN overlap. She was treated in hospital with systemic corticosteroids, antibiotics, intravenous fluids and other supportive measures, and recovered after 3 weeks.

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