Open AccessStevens-Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) overlap associated with carbamazepine use
Author(s) -
Pramod Kumar,
Biju Thomas,
Kishore Kumar,
Sumit Kumar
Publication year - 2005
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.55961
Subject(s) - toxic epidermal necrolysis , carbamazepine , erythema multiforme , dermatology , exfoliative dermatitis , mania , medicine , mucocutaneous zone , rash , chlorpromazine , lamotrigine , erythema , lithium (medication) , bipolar disorder , psychiatry , epilepsy , pharmacology , disease
A benign pruritic rash occurs in 10%-15% of persons treated with carbamazepine. A small fraction of them may experience life-threatening dermatological syndromes such as exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). The case of an 18-year-old female suffering from bipolar affective disorder (mania) who was being treated with carbamazepine, lithium, chlorpromazine and benzhexol is presented. After 10 days of treatment, she developed high-grade fever and mucocutaneous manifestations of SJS-TEN overlap. She was treated in hospital with systemic corticosteroids, antibiotics, intravenous fluids and other supportive measures, and recovered after 3 weeks.