Open AccessREM sleep latency and neurocognitive dysfunction in schizophrenia
Author(s) -
Mrinmay Das,
Ruchika Das,
Udayan Khastgir,
Utpal Goswami
Publication year - 2005
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.55934
Subject(s) - neurocognitive , schizophrenia (object oriented programming) , psychology , polysomnography , cholinergic , neuroscience , impulsivity , cognition , psychiatry , medicine , audiology , electroencephalography
Cognitive deficits-the hallmark of schizophrenic deterioration-still remain elusive as far as their pathophysiology is concerned. Various neurotransmitter systems have been implicated to explain these deficits. Abnormalities in cholinergic neurotransmission in the brain are one of the postulations; acetylcholine has also been postulated to regulate rapid eye movement (REM) sleep, especially REM latency. Thus, REM latency in patients with schizophrenia might provide a non-invasive window to look into the cholinergic functions of the brain.