Quetiapine: Relatively safe in overdose? | Zendy

SurendraK Mattoo | Zendy; Ruchita Shah | Zendy; Rajendra Rajagopal | Zendy; ParthaSarathy Biswas | Zendy; Shubh Mohan Singh | Zendy

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Quetiapine: Relatively safe in overdose?

Author(s) -

SurendraK Mattoo,

Ruchita Shah,

Rajendra Rajagopal,

ParthaSarathy Biswas,

Shubh Mohan Singh

Publication year - 2009

Publication title -

indian journal of psychiatry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.485

H-Index - 34

eISSN - 1998-3794

pISSN - 0019-5545

DOI - 10.4103/0019-5545.49456

Subject(s) - quetiapine , lorazepam , medicine , risperidone , antipsychotic , atypical antipsychotic , anesthesia , psychiatry , schizophrenia (object oriented programming)

Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia (167/minute) and minimal ST depression in leads V1 to V6 on ECG; all other physiological parameters were normal. Gastric lavage, lorazepam 2mg i/v to control agitation, and 14-hour observation in emergency ended in she being sent home. Subsequently she was successfully managed with ECTs, and quetiapine 600mg and risperidone 6mg daily. This report tends to support the literature suggesting quetiapine as a relatively-safer-in-overdose antipsychotic, and preferable in medication-overdose-suicidal-risk cases.

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