Open AccessQuetiapine: Relatively safe in overdose?
Author(s) -
Surendra Kumar Mattoo,
Ruchita Shah,
R. Rajendra,
Partha Biswas,
Shubh Mohan Singh
Publication year - 2009
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.49456
Subject(s) - quetiapine , lorazepam , medicine , risperidone , antipsychotic , atypical antipsychotic , anesthesia , psychiatry , schizophrenia (object oriented programming)
Compared to other antipsychotics quetiapine has been reported to be relatively safer in overdose. We report a case with paranoid schizophrenia who attempted suicide with 1400 mg of quetiapine and manifested drowsiness, supraventricular tachycardia (167/minute) and minimal ST depression in leads V1 to V6 on ECG; all other physiological parameters were normal. Gastric lavage, lorazepam 2mg i/v to control agitation, and 14-hour observation in emergency ended in she being sent home. Subsequently she was successfully managed with ECTs, and quetiapine 600mg and risperidone 6mg daily. This report tends to support the literature suggesting quetiapine as a relatively-safer-in-overdose antipsychotic, and preferable in medication-overdose-suicidal-risk cases.