Open AccessHyperprolactinaemia with amisulpride
Author(s) -
Rajnish Raj,
Balwant Singh Sidhu
Publication year - 2008
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.39761
Subject(s) - amisulpride , hyperprolactinaemia , postsynaptic potential , pharmacology , dopamine , sulpiride , agonist , dopamine receptor d2 , medicine , endocrinology , receptor , prolactin , neuroscience , clozapine , psychology , psychiatry , schizophrenia (object oriented programming) , dopaminergic , hormone
Amisulpride, a substituted benzamide derivative, is a second-generation antipsychotic that preferentially binds to D2/D3 receptors in limbic rather than striatal structures. High dosage preferentially antagonizes postsynaptic receptors, resulting in reduced dopamine transmission; and low dosage blocks presynaptic receptors, resulting in enhanced transmission. Hyperprolactinaemia may occur in patients receiving amisulpride at low dose of 50 mg/day and results in galactorrhoea, amenorrhea and sexual dysfunction. The symptom ameliorates on withdrawing the drug, switching to non-prolactin-elevating drugs, and timely management with dopamine agonist.