Open AccessIloperidone-induced ejaculatory dysfunction: A case series
Author(s) -
Niraj Ravani,
Pramod Katke
Publication year - 2016
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.174392
Subject(s) - ejaculation , dopamine , sexual dysfunction , receptor , medicine , antagonist , dopamine receptor , pharmacology , retrograde ejaculation , endocrinology , prostate , cancer
Disorders of ejaculation are the consequences of surgical procedures and with the use of various drugs. Until date, most drugs reported to induce ejaculatory dysfunctions such as retrograde ejaculation or dry orgasms share the capacity to significantly antagonize alpha 1-adrenergic receptor. Iloperidone, a new dopamine Type 2 and serotonin Type 2A antagonist similar to risperidone, provides better efficacy with lesser extra-pyramidal side effects. In addition, it also antagonize alpha 1-adrenergic receptor and alpha-2C receptors. Limited data is available for iloperidone-induced ejaculation dysfunction. This article features five schizophrenic patients which developed retrograde ejaculation during treatment with iloperidone. The ejaculatory dysfunction following treatment with iloperidone could be postulated due to blocking of alpha 1-adrenergic receptor.