Open AccessMarchiafawa bignami disease possibly related to consumption of a locally brewed alcoholic beverage: Report of two cases
Author(s) -
Jagdeo Prasad Rawat,
Charles Pinto,
Kapil Kulkarni,
M. Ananthi K Muthusamy,
Malay Dave
Publication year - 2014
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.124720
Subject(s) - splenium , corpus callosum , wine , medicine , disease , alcohol consumption , pathology , alcohol , food science , chemistry , white matter , radiology , magnetic resonance imaging , biochemistry
Marchiafava Bignami disease is a rare toxic disease seen mostly in chronic alcoholics, resulting in progressive demyelination and necrosis of the corpus callosum. Initially it was thought to be specific to individuals in central Italy, consuming large amounts of Chianti red wine; however, alcoholic beverages worldwide are presently implicated. In our case series of two cases, locally made "illicit" liquor (Mahuwa Alcohol) could be the causative factor. In radiological point of view typically the corpus callosum is affected, with involvement of the body, genu, and splenium in order of occurrence. Occasionally the entire callosum may be also involved. Clinical presentation varies from case to case.