Open AccessVentricular premature contractions associated with iloperidone
Author(s) -
Rashmin Achalia,
Chittaranjan Andrade
Publication year - 2013
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.111464
Subject(s) - asenapine , olanzapine , medicine , risperidone , qt interval , thioridazine , atypical antipsychotic , antipsychotic , cardiology , pharmacology , anesthesia , schizophrenia (object oriented programming) , chlorpromazine , psychiatry
Typical and atypical antipsychotic drugs are known to block potassium repolarization channels, prolong the QTc interval, and thereby predispose to ventricular tachyarrhythmias. We report a young male schizophrenic patient who experienced clinically significant and symptomatically distressing ventricular premature contractions (VPCs) in close temporal relation with iloperidone (8-16 mg/day) treatment; there had been no VPCs with prior exposure to risperidone, trihexyphenidyl, and olanzapine, nor with subsequent exposure to asenapine. We hypothesize that the VPCs may have been triggered by an alpha 2c receptor blockade-mediated cardiostimulatory action associated with iloperidone.