Open AccessAdding antidepressants to antipsychotics for treatment of subsyndromal depressive symptoms in schizophrenia: Impact on positive and negative symptoms
Author(s) -
Ipsit Vahia,
Nicole M. Lanouette,
Shahrokh Golshan,
Ian E. Fellows,
Somaia Mohamed,
John Kasckow,
Sidney Zisook
Publication year - 2013
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.111452
Subject(s) - schizoaffective disorder , citalopram , positive and negative syndrome scale , schizophrenia (object oriented programming) , psychiatry , antidepressant , psychology , placebo , depressive symptoms , depression (economics) , clinical psychology , randomized controlled trial , medicine , major depressive disorder , psychosis , anxiety , cognition , alternative medicine , macroeconomics , pathology , economics
It remains unclear how augmenting anti-psychotic medications with anti-depressants impacts primary positive and negative symptoms of schizophrenia. In this study, we used data collected from a randomized trial comparing citalopram to placebo for management of subsyndromal depression (SSD) in schizophrenia and schizoaffective disorder, to assess the effects of antidepressant augmentation on positive and negative symptoms.