Open AccessSafety and efficacy of donepezil hydrochloride in patients with mild to moderate Alzheimer′s disease: Findings of an observational study
Author(s) -
Suyog Mehta,
K Chandersekhar,
G Prasadrao,
Lakshman Dutt,
Shraddha Patkar,
Rajesh Nagpal,
Meena Gupta,
G. Suryanarayana Raju,
Karishma Praveen,
Bhavan Prasad,
Trishit Roy,
Suman Kushwaha,
Jyotindra Nag,
Deepak Langade,
Dilip Pawar
Publication year - 2012
Publication title -
indian journal of psychiatry/indian journal of psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.485
H-Index - 34
eISSN - 1998-3794
pISSN - 0019-5545
DOI - 10.4103/0019-5545.104820
Subject(s) - donepezil , dementia , medicine , adverse effect , acetylcholinesterase , rating scale , clinical dementia rating , cholinesterase , dose , activities of daily living , observational study , disease , psychology , physical therapy , developmental psychology , biochemistry , chemistry , enzyme
Alzheimer's disease (AD), a progressive brain disorder, is the most common cause of dementia among the elderly. Donepezil hydrochloride is a potent, reversible, and highly selective inhibitor of acetylcholinesterase (AChE). It is chemically distinct from other cholinesterase (ChE) inhibitors which are effective in the treatment of AD.