Open AccessChondrocyte source for cartilage regeneration in an immature animal: Is iliac apophysis a good alternative?
Author(s) -
Karthikeyan Rajagopal,
Vivek Dutt,
A. Manickam,
Vrisha Madhuri
Publication year - 2012
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.98828
Subject(s) - chondrocyte , cartilage , chondrogenesis , laboratory flask , medicine , anatomy , regeneration (biology) , tissue engineering , articular cartilage repair , articular cartilage , andrology , transplantation , osteoarthritis , surgery , pathology , biomedical engineering , microbiology and biotechnology , biology , chemistry , alternative medicine
Autologous articular cartilage at present forms the main source of chondrocytes for cartilage tissue engineering. In children, iliac apophysis is a rich and readily accessible source of chondrocytes. This study compares the growth characteristics and phenotype maintenance of goat iliac apophysis growth plate chondrocytes with those sourced from goat articular cartilage, and thereby assesses their suitability for autologous chondrocyte transplantation in immature animals for growth plate and articular cartilage regeneration.