Open AccessDegenerated intervertebral disc prolapse and its association of collagen I alpha 1 Spl gene polymorphism
Author(s) -
Shailendra Anjankar,
Subhadra Poornima,
Subodh Raju,
Momin Abdul Jaleel,
Dilnavaz Bhiladvala,
Qurratulain Hasan
Publication year - 2015
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.168765
Subject(s) - medicine , intervertebral disc , alpha (finance) , polymorphism (computer science) , association (psychology) , anatomy , genotype , gene , surgery , genetics , biology , construct validity , philosophy , epistemology , patient satisfaction
Degenerated disc disease (DDD) is a common disorder responsible for increased morbidity in a productive age group. Its etiology is multifactorial and genetic factors have been predominantly implicated. Disc prolapse results due to tear in the annulus, which is a fibrous structure composed largely of type I collagen. Functional polymorphism at the Sp1 site of the collagen I alpha 1 (COL1A1) gene has shown a positive association with DDD in Dutch and Greek populations. The purpose of this study was to assess COL1A1 Sp1 gene polymorphism in the Indian population.