Open AccessFractalkine receptor chemokine (CX3CR1) influences on cervical and lumbar disc herniation
Author(s) -
In-Soo Oh,
Dongwhan Suh,
Sung-Ryeoll Park,
Kee-Yong Ha
Publication year - 2015
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.152505
Subject(s) - cx3cr1 , cx3cl1 , medicine , chemokine , chemokine receptor , pathology , immunology , inflammation
Herniation of nuclear or disc material along with, inflammatory chemokines such as prostaglandin E2, interleukin-6, matrix metalloproteinase and nitric oxide has definite correlation, possibly they are over produced. CX3CL1 and its receptor (CX3CR1) are part of chemokine system involved in leukocyte recruitment and adhesion in chronic inflammatory disease, but its role in spinal herniated nucleus pulposus (HNP) is unknown. We evaluated the expression of CX3CL1 and CX3CR1 in patients with disc herniation to clarify the role of CX3CL1 and CX3CR1 in the disc degeneration and to compare between cervical and lumbar HNP.