Open AccessKlebsiella pneumoniae carrying blaNDM-1 gene in orthopedic practice
Author(s) -
Varsha Gupta,
Neha Bansal,
Ravi Gupta,
Jagdish Chander
Publication year - 2014
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.139888
Subject(s) - klebsiella pneumoniae , colistin , tigecycline , medicine , microbiology and biotechnology , polymyxin b , imipenem , gene , biology , antimicrobial , antibiotics , antibiotic resistance , genetics , escherichia coli
Emergence and spread of carbapenemases in Enterobacteriaceae is a cause of concern worldwide, the latest threat being New Delhi metallo-β-lactamase (NDM-1). This report is of an orthopedic case with fracture femur managed with internal fixation and bone grafting, who subsequently developed secondary infection with Klebsiella pneumoniae harboring bla NDM-1 gene. Minimum inhibitory concentration (MIC) of imipenem was ≥8 μg/ml by E-test, suggestive of carbapenemase production. Phenotypic and further genotypic detection confirmed the presence of bla NDM-1 gene. The isolate remained susceptible only to tigecycline, colistin, and polymyxin B.