Open AccessBony defect repair in rabbit using hybrid rapid prototyping polylactic-co-glycolic acid/β-tricalciumphosphate collagen I/apatite scaffold and bone marrow mesenchymal stem cells
Author(s) -
Long Pang,
Hao Wu,
Ming Jiang,
Jikun Huang,
Yonggang Yan,
Yunyu Hu
Publication year - 2013
Publication title -
indian journal of orthopaedics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.434
H-Index - 33
eISSN - 1998-3727
pISSN - 0019-5413
DOI - 10.4103/0019-5413.114927
Subject(s) - medullary cavity , biomedical engineering , scaffold , apatite , plga , medicine , mesenchymal stem cell , polylactic acid , bone healing , tissue engineering , bone marrow , glycolic acid , biomaterial , hyaluronic acid , materials science , anatomy , pathology , chemistry , biology , composite material , nanotechnology , lactic acid , mineralogy , genetics , nanoparticle , bacteria , polymer
In bone tissue engineering, extracellular matrix exerts critical influence on cellular interaction with porous biomaterial and the apatite playing an important role in the bonding process of biomaterial to bone tissue. The aim of this study was to observe the therapeutic effects of hybrid rapid prototyping (RP) scaffolds comprising polylactic-co-glycolic acid (PLGA), β-tricalciumphosphate (β-TCP), collagen I and apatite (PLGA/β-TCP-collagen I/apatite) on segmental bone defects in conjunction with combination with bone marrow mesenchymal stem cells (BMSCs).