Open AccessOxidative stress effects of thinner inhalation
Author(s) -
Minerva Martínez-Alfaro,
Yolanda Alcaraz-Contreras,
Alfonso Cárabez-Trejo,
Guillermo Enrique Leo-Amador
Publication year - 2011
Publication title -
the indian journal of occupational and environmental medicine/the indian journal of occupational and environmental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.375
H-Index - 26
eISSN - 1998-3670
pISSN - 0973-2284
DOI - 10.4103/0019-5278.93195
Subject(s) - oxidative stress , inhalation , lipid peroxidation , antioxidant , chemistry , oxidative phosphorylation , oxidative damage , medicine , biochemistry , anesthesia
Thinners are chemical mixtures used as industrial solvents. Humans can come into contact with thinner by occupational exposure or by intentional inhalation abuse. Thinner sniffing causes damage to the brain, kidney, liver, lung, and reproductive system. We discuss some proposed mechanism by which thinner induces damage. Recently, the induction of oxidative stress has been suggested as a possible mechanism of damage. This paper reviews the current evidence for oxidative stress effects induced by thinner inhalation. Early ideas about the effects of thinner on lipids are discussed in one section. We discuss several studies that have shown the oxidative effects of thinner inhalation on: lipid peroxidation, levels of antioxidant enzymes, glutathione depletion, and oxidation of proteins and DNA. We have also included studies about oxidative stress effects induced by toluene, the principal component (60-70%) of thinner. Finally, work describing the effects of oxidative stress induced by thinner inhalation on different organs is discussed.