Open AccessNeopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers
Author(s) -
Shubhangi K. Pingle,
Lucky Thakkar,
Aruna A. Jawade,
Rajani G. Tumane,
Ruchika Jain,
Pravin Soni
Publication year - 2015
Publication title -
the indian journal of occupational and environmental medicine/the indian journal of occupational and environmental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.375
H-Index - 26
eISSN - 1998-3670
pISSN - 0973-2284
DOI - 10.4103/0019-5278.165332
Subject(s) - neopterin , creatinine , toxicity , bauxite , oxidative stress , biomarker , medicine , zoology , toxicology , chemistry , biology , biochemistry
Bauxite ore is a major source of aluminum (Al) which contains approximately 35-60% Al by weight. Occupational and environmental bauxite dust exposure may cause toxicity by interaction with human biological systems resulting in oxidative stress (OS) and cell death. A neopterin derivative as an antioxidant is able to modulate cytotoxicity by the induction of OS.