Open AccessNeopterin: A candidate biomarker for the early assessment of toxicity of aluminum among bauxite dust exposed mine workers
Author(s) -
ShubhangiK Pingle,
LuckyR Thakkar,
ArunaA Jawade,
RajaniG Tumane,
RuchikaK Jain,
PravinN Soni
Publication year - 2015
Publication title -
indian journal of occupational and environmental medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.375
H-Index - 26
eISSN - 1998-3670
pISSN - 0973-2284
DOI - 10.4103/0019-5278.165332
Subject(s) - neopterin , creatinine , toxicity , bauxite , oxidative stress , biomarker , medicine , zoology , toxicology , chemistry , biology , biochemistry
Bauxite ore is a major source of aluminum (Al) which contains approximately 35-60% Al by weight. Occupational and environmental bauxite dust exposure may cause toxicity by interaction with human biological systems resulting in oxidative stress (OS) and cell death. A neopterin derivative as an antioxidant is able to modulate cytotoxicity by the induction of OS.
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