Open AccessThe role of cytokines in the pathomechanism of cutaneous disorders
Author(s) -
Arijit Coondoo
Publication year - 2012
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.94272
Subject(s) - cytokine , signal transduction , immune system , inflammation , immunology , receptor , microbiology and biotechnology , pathogenesis , biology , genetics
Cytokines are produced transiently by cutaneous cells in response to immune stimuli. They are non-immunoglobulin proteins and glycoproteins. Cytokines, which are signaling molecules, act by sending downstream signals to various cells through a number of signal transduction pathways and by binding to cytokine receptors on the surface of cells. Cytokines regulate immunity and inflammation and thus play an important role in the pathogenesis of various cutaneous disorders.