Open AccessAllogenic hematopoietic stem cell transplantation in pemphigus vulgaris: A single-center experience
Author(s) -
Aruna V Vanikar,
Hargovind L Trivedi,
Rashmi D Patel,
Kamal V Kanodia,
Pranjal Modi,
Veena R Shah
Publication year - 2012
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.92667
Subject(s) - medicine , pemphigus vulgaris , hematopoietic stem cell transplantation , stem cell , bone marrow , cd34 , graft versus host disease , single center , group b , transplantation , autoantibody , gastroenterology , immunology , antibody , biology , genetics
Pemphigus vulgaris (PV), an autoimmune disorder characterized by blistering skin/mucus membrane lesions, is mediated by desmoglein-3 autoantibodies. We carried out a prospective clinical trial of hematopoietic stem cell transplantation (HSCT) in thymus, bone marrow (BM) and periphery to reconstitute central and peripheral arms of self-tolerance.