Open AccessDress syndrome with sepsis, acute respiratory distress syndrome and pneumomediastinum
Author(s) -
Prabhas Prasun Giri,
Swapan Kumar Roy,
Sukanta Bhattyacharya,
Priyankar Pal,
Sandipan Dhar
Publication year - 2011
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.91850
Subject(s) - medicine , rash , ards , dermatology , eosinophilia , respiratory distress , carbamazepine , sepsis , pneumonitis , phenytoin , anesthesia , immunology , lung , epilepsy , psychiatry
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, and is characterized by skin rash, fever, lymph node enlargement, and internal organ involvement. So far, numerous drugs such as sulfonamides, phenobarbital, sulfasalazine, carbamazepine, and phenytoin have been reported to cause DRESS syndrome. We report a case of a 10-year-old girl who developed clinical manifestations of fever, rash, lymphadenopathy, hypereosinophilia, and visceral involvement (hepatitis and pneumonitis) after taking phenobarbital for seizures, with subsequent development of sepsis, acute respiratory distress syndrome (ARDS) and spontaneous air leak syndrome (pnemothorax and pneumomediastinum). She was put on steroids and various antibiotics and was ventilated, but ultimately succumbed to sepsis and pulmonary complications.