Open AccessCongenital lupus erythematosus
Author(s) -
Taseer Ahmed Bhatt,
Hanadi Fatani,
Samara Mimesh
Publication year - 2011
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.91841
Subject(s) - medicine , subacute cutaneous lupus erythematosus , histopathology , dermatology , systemic lupus erythematosus , transplacental , lupus erythematosus , autoimmune disease , pathology , skin biopsy , disease , connective tissue disease , biopsy , immunology , fetus , pregnancy , antibody , placenta , genetics , biology
Neonatal lupus erythematosus (NLE) is an autoimmune disease affecting the fetus as a result of transplacental transfer of anti-Ro autoantibodies. Typically, it presents in the first few months of life with an annular form of subacute cutaneous lupus erythematosus. We report an unusual case of NLE presenting at birth with scaly erythematous telangiectatic patches and macules with skin atrophy involving the face, head, and upper trunk. Thrombocytopenia was discovered on laboratory investigations. Histopathology of skin biopsy was consistent with subacute cutaneous lupus. The mother was clinically free of disease and had no family history of autoimmune disease. Serology (extra-nuclear antigens) was positive in both the baby and the mother. This is a rare presentation of a rare disease.