Open AccessAssessment of serum homocysteine, endothelin-1, and nitric oxide levels in behçet′s disease
Author(s) -
Abeer A Hodeib,
Tarek A Elsharawy,
Hisham Ahmed Fawzi
Publication year - 2010
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.70667
Subject(s) - hyperhomocysteinemia , homocysteine , medicine , nitric oxide , endothelial dysfunction , gastroenterology , platelet activation , behcet's disease , endothelin receptor , nitrite , endocrinology , immunology , platelet , disease , chemistry , receptor , organic chemistry , nitrate
Some prominent features of Behçet's disease (BD) are arterial and venous thromboses as a result of endothelial dysfunction. Hyperhomocysteinemia is responsible for vascular endothelial injury due to an increased frequency of thrombogenesis. Endothelin-1 (ET-1) is a vasoconstrictor whereas nitric oxide (NO) is an endothelial vasorelaxing peptide that is responsible for the inhibition of platelet adhesion.