Open AccessTargeting IL-23: Insights into the pathogenesis and the treatment of psoriasis
Author(s) -
Hermenio Lima,
Alexa B. Kimball
Publication year - 2010
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.62760
Subject(s) - psoriasis , medicine , psoriatic arthritis , therapeutic modalities , pathogenesis , modalities , treatment modality , dermatology , immunology , bioinformatics , social science , sociology , biology
Therapeutic experience strongly supports the use of TNF antagonists as important modalities in the treatment of psoriatic arthritis and plaque psoriasis. Studies with anti-IL-12/23 therapeutic agents, which act in different steps of the psoriatic inflammatory cascade, have also shown demonstrable efficacy. Here, we discuss this approach and its potential within the armamentarium for the treatment of psoriasis. Evidences that the selective blocking of IL-23 may be effective and safe therapy are also addressed.