Open AccessLupus anticoagulant and leg ulcers in sickle cell anemia
Author(s) -
Edeghonghon Olayemi,
GN Bazuaye
Publication year - 2009
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.55635
Subject(s) - medicine , lupus anticoagulant , hemolysis , odds ratio , sickle cell anemia , anemia , incidence (geometry) , immunology , gastroenterology , systemic lupus erythematosus , antibody , disease , physics , optics
The cause of chronic leg ulcer (CLU) in patients with sickle cell anemia (SCA) is unknown; it has been attributed to hypercoagulability associated with the disease. Recently, it has been suggested that a subset of SCA patients may be prone to developing CLU and that hemolysis may be an underlying factor in the development of CLU. The lupus anticoagulant (LA) is an antiphospholipid antibody (aPLa), these antibodies have been described in patients with SCA.