Open AccessSerum mucosa-associated epithelial chemokine in atopic dermatitis : A specific marker for severity
Author(s) -
Mohamed Ezzat,
Karim Y. Shaheen
Publication year - 2009
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.55630
Subject(s) - medicine , atopic dermatitis , chemokine , gastroenterology , asthma , ccr3 , immunology , inflammation , chemokine receptor
Mucosa-associated epithelial chemokine (MEC; CCL28) is considered pivotal in mediating migration of CCR3 and CCR10-expressing skin-homing memory CLA(+) T cells. CCL28 is selectively and continuously expressed by epidermal keratinocytes, but highly upregulated in inflammatory skin diseases such as atopic dermatitis (AD).