Open AccessUnusual presentation of generalized macular amyloidosis in a young adult
Author(s) -
Mohan H Kudur,
Sathish B Pai,
H Sripathi,
Smitha Prabhu
Publication year - 2008
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.44802
Subject(s) - acanthosis , medicine , hyperkeratosis , amyloidosis , dermatology , histopathology , pathology , lesion , papillary dermis , spongiosis , hypopigmentation , dermis
Macular amyloidosis is a common problem seen dermatology out-patient department. Generalized macular amyloidosis presenting with a poikilodermatous appearance is rare. In our case, an 18-year-old male presented with generalized hypopigmented macules with a poikilodermatous appearance of 10-year duration. His developmental milestones were normal with negative family history of similar complaints. Histopathology of hyperpigmented lesions revealed hyperkeratosis and acanthosis of epidermis and hypopigmented lesion showing only hyperkeratosis. Both lesions were showing the deposition of amorphous, hazy material in the tips of papillary dermis with perivascular inflammatory infiltrate. Congo red staining of the amorphous material was positive for amyloid.