Open AccessA rare case of juvenile systemic lupus erythematosus with disseminated histoplasmosis
Author(s) -
Prasanta Kumar Sarkar,
Keya Basu,
Madhumita Sinha
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.193710
Subject(s) - histoplasmosis , medicine , histoplasma capsulatum , dimorphic fungus , histoplasma , disease , septic shock , dermatology , juvenile , immunology , mycosis , systemic disease , pathology , sepsis , biology , genetics , yeast
Histoplasmosis is a systemic fungal infection caused by dimorphic fungus, Histoplasma capsulatum. Immunocompetent individuals usually have self-limiting or localized disease whereas immunocompromised individuals develop disseminated disease. The occurrence of progressive disseminated histoplasmosis in juvenile systemic lupus erythematosus is extremely rare with only one reported case in literature showing such association. Therefore, we report a case of severe opportunistic fungal infection caused by Histoplasma in a 13-year-old girl who was diagnosed with juvenile lupus erythematosus, subsequently developed septic shock and died of the disease despite of aggressive antifungal therapy