Open AccessGranular IgM deposition at basement membrane zone in an infant with diffuse cutaneous mastocytosis
Author(s) -
Subramanian Kumudhini,
Raghavendra Rao,
Gauri A Salgaonkar,
Shricharith Shetty,
Sathish Pai
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.190134
Subject(s) - medicine , dermatology , basement membrane , pathology
Diffuse Cutaneous mastocytosis (DCM) occurs due to abnormal accumulation of mast cells in the skin. We report an 8-month-old infant presented papulovesicular lesions, predominantly on the trunk. Skin biopsy revealed subepidermal bulla, interspersed with mast cells, eosinophils and neutrophils. Direct immunofluorescence microscopy of perilesional skin revealed nonspecific deposition of IgM in granular pattern along the dermoepidermal junction