Open AccessSignificance of anti-cyclic citrullinated peptide autoantibodies in immune-mediated inflammatory skin disorders with and without arthritis
Author(s) -
Chander Grover,
Bineeta Kashyap,
Deepashree Daulatabad,
Amit Dhawan,
Inderdeep Kaur
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.190122
Subject(s) - medicine , connective tissue , autoantibody , rheumatoid factor , immune system , psoriasis , rheumatoid arthritis , mixed connective tissue disease , immunology , arthritis , antibody , pemphigus foliaceus , pathology
Anti-cyclic citrullinated peptides (CCPs) are autoantibodies directed against citrullinated peptides. Rheumatoid factor (RF), an antibody against the Fc portion of IgG, is known to form immune complexes and contribute to the etiopathogenesis of various skin disorders. C-reactive protein (CRP), an acute-phase protein, increases following secretion of interleukin-6 from macrophages and T cells. Anti-CCP, RF, and CRP are well-established immune-markers, their diagnostic potential in immune-mediated skin disorders remains less widely studied.