Open AccessChronic eosinophilic leukemia presenting predominantly with cutaneous manifestations
Author(s) -
Suja Vidyadharan,
Bebisha Joseph,
Sukumaran Pradeep Nair
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.185716
Subject(s) - medicine , eosinophilia , eosinophilic , eosinophil , pathology , imatinib mesylate , leukemia , dermatology , imatinib , immunology , myeloid leukemia , asthma
A 37-year-old male presented with severe oral and genital mucosal ulcers, lichenoid eruption and twenty-nail dystrophy. Systemic examination was normal, except for anemia. On investigations, he was found to have persistently elevated peripheral eosinophilia, absolute eosinophil count >5000/mm(3), bone marrow showing increased eosinophilic precursors, and infiltration by atypical cells. The serum vitamin B12 levels were grossly elevated, and Philadelphia chromosome study was negative. Thus, a diagnosis of chronic eosinophilic leukemia was made. The patient showed excellent response to imatinib mesylate. We are reporting a rare type of leukemia presenting with predominantly cutaneous manifestations.