Open AccessHeat shock protein-70 expression in vitiligo and its relation to the disease activity
Author(s) -
Reham William Doss,
Abdel-Aziz El-Rifaie,
Amr M Abdel-Wahab,
Yasser Gohary,
Laila Ahmed Rashed
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.185704
Subject(s) - vitiligo , medicine , pathogenesis , psoriasis , heat shock protein , disease , immunology , autoimmune disease , real time polymerase chain reaction , dermatology , pathology , gene , biology , biochemistry
Vitiligo is a progressive depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. The etiopathogenesis of vitiligo is still unclear. Heat shock proteins (HSPs) are prime candidates to connect stress to the skin. HSPs were found to be implicated in autoimmune diseases such as rheumatoid arthritis and other skin disorders as psoriasis.