Open AccessRole of osteopontin in psoriasis: An immunohistochemical study
Author(s) -
Mahmoud Yousry Abdel-Mawla,
Kamal Ahmed El-Kasheshy,
Soheir Ghonemy,
Walid Al Balat,
Amira Ahmed Elsayed
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.182434
Subject(s) - osteopontin , medicine , psoriasis , pathogenesis , proinflammatory cytokine , immunohistochemistry , keratinocyte , downregulation and upregulation , psoriasis area and severity index , immunology , apoptosis , pathology , inflammation , biology , cell culture , gene , biochemistry , genetics
Osteopontin (OPN) has been postulated to have a role in several T-helper (Th) 1 and Th 17-mediated diseases including psoriasis (PS), through multiple mechanisms sharing in the onset and worsening of PS, OPN shares in induction of keratinocyte proliferation through inhibiting keratinocyte apoptosis, OPN acts as a proinflammatory agent that participates in the upregulation of Th cell lineages, among which are the Th 1 and Th 17 cells.