Role of osteopontin in psoriasis: An immunohistochemical study | Zendy

Soheir Ghonemy | Zendy; MYousry Abdel-Mawla | Zendy; KamalAhmed El-Kasheshy | Zendy; Walid Al Balat | Zendy; AmiraAhmed Elsayed | Zendy

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Role of osteopontin in psoriasis: An immunohistochemical study

Author(s) -

Soheir Ghonemy,

MYousry Abdel-Mawla,

KamalAhmed El-Kasheshy,

Walid Al Balat,

AmiraAhmed Elsayed

Publication year - 2016

Publication title -

indian journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.395

H-Index - 36

eISSN - 1998-3611

pISSN - 0019-5154

DOI - 10.4103/0019-5154.182434

Subject(s) - osteopontin , medicine , psoriasis , pathogenesis , proinflammatory cytokine , immunohistochemistry , keratinocyte , downregulation and upregulation , psoriasis area and severity index , immunology , apoptosis , pathology , inflammation , biology , cell culture , gene , biochemistry , genetics

Osteopontin (OPN) has been postulated to have a role in several T-helper (Th) 1 and Th 17-mediated diseases including psoriasis (PS), through multiple mechanisms sharing in the onset and worsening of PS, OPN shares in induction of keratinocyte proliferation through inhibiting keratinocyte apoptosis, OPN acts as a proinflammatory agent that participates in the upregulation of Th cell lineages, among which are the Th 1 and Th 17 cells.

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