Open AccessLamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma
Author(s) -
Friedrich K. Stephan,
Richard M. Haber,
Elio Kechichian,
François G. Kamar
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.177784
Subject(s) - medicine , lamotrigine , rash , lymphoma , cd30 , dermatology , presentation (obstetrics) , pathology , eosinophilia , hypersensitivity reaction , lymph node biopsy , immunology , epilepsy , surgery , psychiatry
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic lymphomas. We report the first case of a lamotrigine-induced DRESS with histologic features of a cutaneous CD30+ lymphoma. The patient responded well to a tapering course of oral steroids. This case highlights the atypical presentation of a lamotrigine-induced DRESS/DIHS in the presence of a cutaneous and a lymph node CD30 + lymphocytic infiltrate mimicking systemic lymphoma. Pathologists and clinicians must be aware of this “lymphomatous” presentation of drug reactions