Open AccessInterchanging autoimmunity - lupus mastitis coexisting with systemic polyarteritis nodosa
Author(s) -
Mary Vineetha,
Seena Palakkal,
Kunjumani Sobhanakumari,
MI Celine
Publication year - 2016
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.177759
Subject(s) - medicine , anti nuclear antibody , polyarteritis nodosa , systemic lupus erythematosus , dermatology , mastitis , rheumatology , etiology , autoimmunity , pathology , connective tissue , immunology , vasculitis , disease , antibody , autoantibody
Lupus mastitis is an uncommon presentation of lupus erythematosus profundus (LE profundus), characterized by inflammation of the subcutaneous fat. LE profundus occurring as initial manifestation of LE is rare. We report a case where the patient presented with lupus mastitis and years later, she developed disseminated discoid LE (DLE) and polyarteritis nodosa (PAN). PAN and DLE are connective tissue diseases with different etiologies, clinical, immunological, and histopathological features. One connective tissue disease evolving into another is rare, and the reasons remain unexplained. This woman had histopathologically proven DLE and lupus mastitis with a negative antinuclear antibody profile. She satisfied the American College of Rheumatology criteria for PAN.