Open AccessSirolimus as long-term graft-versus-host-disease prophylaxis in haploidentical hematopoietic stem cell transplant recipients for non-malignant disorders is associated with high incidence of acneiform lesions
Author(s) -
Aditi Chakrbarti,
Sarita Rani Jaiswal,
Suparno Chakrabarti
Publication year - 2015
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.169131
Subject(s) - medicine , sirolimus , incidence (geometry) , graft versus host disease , hematopoietic stem cell transplantation , stem cell , disease , hematopoietic stem cell , haematopoiesis , optics , biology , genetics , physics
Sirolimus has provided the option for calcineurin inhibitor (CNI)-free immunosuppressive therapy in both solid organ transplant (SOT) and hematopoietic stem cell transplantation (HSCT). However, long-term use of sirolimus has been reported to be associated with a high incidence of cutaneous side effects in SOT, particularly acneiform lesions.