Open AccessAcral acanthosis nigricans in a case of scleroderma
Author(s) -
Mahendra M Kura,
Swapnil A Sanghavi
Publication year - 2015
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.160540
Subject(s) - acanthosis nigricans , medicine , intertriginous , dermatology , insulin resistance , malignancy , scleroderma (fungus) , polycystic ovary , autoimmune disease , diabetes mellitus , pathology , disease , endocrinology , inoculation
Acanthosis nigricans (AN) is a dermatosis characterized by velvety, papillomatous, brownish-black, hyperkeratotic plaques, typically on the intertriginous surfaces and neck. The majority (80%) of AN occurs idiopathically or in benign conditions such as endocrinopathies like diabetes mellitus, polycystic ovary syndrome; metabolic syndrome and/or heritable disease. Malignancy-associated AN is rare. AN may rarely be associated with autoimmune diseases including systemic lupus erythematosus, due to antibodies to the insulin receptor, so-called type B insulin resistance. Here we report a case of AN in a case of diffuse progressive systemic sclerosis without evidence of insulin resistance