Open AccessDarier′s disease in gastric malignancy: An unusual paraneoplastic phenomenon
Author(s) -
Anusree Gangopadhyay,
Alakendu Ghosh,
Samar Biswas,
Joydeep Singha,
Ishad Aggarwal,
Gobinda Chatterjee
Publication year - 2015
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.160535
Subject(s) - medicine , genodermatosis , dermatology , malignancy , darier's disease , disease , adenocarcinoma , histopathology , dyskeratosis , pathology , cancer , hyperkeratosis , biochemistry , chemistry , gene
Darier′s disease is an autosomal dominant genodermatosis resulting from ATP2A2 gene mutation. A 62-year-old male presented at our outpatient (OPD) with sudden-onset numerous dirty, warty papules over the head, neck, and back since 2 months. Histopathology of the skin lesions revealed acantholytic dyskeratosis suggestive of Darier′s disease. He was referred to the gastroenterology department for some gastrointestinal (GI) symptoms where he was diagnosed with adenocarcinoma of the stomach and was subsequently operated. On his next visit to our department for follow-up, we found a marked diminution of the skin lesions in the absence of any specific treatment. In view of the above finding, we concluded that paraneoplastic dermatosis in the form of Darier′s disease occurred in this patient. Paraneoplastic Darier′s disease with gastric adenocarcinoma is not yet described in dermatology literature and is hence reported here