Open AccessTherapeutic plasma exchange-A new dawn in the treatment of pemphigus vulgaris
Author(s) -
Rajesh Kumar,
Aikaj Jindal,
Amarjit Kaur,
Saloni Gupta
Publication year - 2015
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.160509
Subject(s) - pemphigus vulgaris , medicine , therapeutic effect , refractory (planetary science) , autoantibody , dermatology , pemphigus , immunology , therapeutic plasma exchange , mucous membrane , concomitant , antibody , gastroenterology , physics , astrobiology
Pemphigus vulgaris is an autoimmune disorder that involves intraepithelial blistering and sores of skin and mucous membrane. It generally correlates with the levels of circulating autoantibodies; their removal seems a reasonable therapeutic approach. Therapeutic plasma exchange is hypothesized to remove pathogenic autoantibodies and has been used in refractory or severe cases. It may be considered for rapid control of severe or recalcitrant pemphigus vulgaris and should be combined with use of concomitant immuno-suppressive