Open AccessUnique TTC repeat base pair loss mutation in cases of pure neural leprosy: A survival strategy of Mycobacterium leprae?
Author(s) -
Abhishek De,
Abu Hena Hasanoor Reja,
Supratik Biswas,
Basudev Bhattacharya,
Gobinda Chatterjee,
Keya Basu,
Aarti Sarda,
Nidhi Chowdhury
Publication year - 2015
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.160478
Subject(s) - mycobacterium leprae , biology , genetics , mutation , rpob , tandem repeat , gene , subcloning , leprosy , genome , plasmid , immunology , 16s ribosomal rna
Genomic reduction helps obligate intracellular microbes to survive difficult host niches. Adaptation of Mycobacterium leprae in cases of pure neural leprosy (PNL) in the intracellular niche of peripheral nerves can be associated with some gene loss. Recently, a stable but variable number of tandem repefzats (TTC) have been reported in strains of M. leprae. FolP and rpoB genes are the two common mutation sites which deal with the susceptibility of the bacteria to drugs.