A comprehensive study of tumor necrosis factor-alpha genetic polymorphisms, its expression in skin and relation to histopathological features in psoriasis | Zendy

Biju Vasudevan | Zendy; NikhilN Moorchung | Zendy; Manas Chatterjee | Zendy; Rajan Grewal | Zendy; NarayanaS Mani | Zendy

Open Access

A comprehensive study of tumor necrosis factor-alpha genetic polymorphisms, its expression in skin and relation to histopathological features in psoriasis

Author(s) -

Biju Vasudevan,

NikhilN Moorchung,

Manas Chatterjee,

Rajan Grewal,

NarayanaS Mani

Publication year - 2015

Publication title -

indian journal of dermatology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.395

H-Index - 36

eISSN - 1998-3611

pISSN - 0019-5154

DOI - 10.4103/0019-5154.160477

Subject(s) - psoriasis , medicine , genotyping , genotype , allele , tumor necrosis factor alpha , pathogenesis , immunohistochemistry , immunology , pathology , gene , biology , genetics

Tumor necrosis factor-alpha (TNFα) is an important inflammatory mediator in psoriasis and several genetic polymorphisms of this cytokine have been reported. Majority of studies have focused on the increased G- A polymorphism at the -308 position in psoriasis. There has been no comprehensive study evaluating the genetic polymorphisms, TNFα expression in the skin and histopathology. We are undertaking this study to outline TNFα genetic polymorphisms, its skin expression and histopathological correlation to help determine its role at the genetic and protein level.

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