Open AccessSteroid-resistant autoimmune thrombocytopenia in systemic lupus erythematosus treated with rituximab
Author(s) -
Vasudha V Sardesai,
Vidyadhar R Sardesai,
Trupti D Agarwal
Publication year - 2015
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.147874
Subject(s) - medicine , rituximab , autoimmune hemolytic anemia , immunology , autoantibody , monoclonal antibody , monoclonal , autoimmunity , autoimmune thrombocytopenia , antibody
Systemic Lupus Erythematosus (SLE) is a multisystem disorder characterized by production of numerous autoantibodies, some of which have pathogenic consequences and result in considerable morbidity. Herein, we present a case of 48-year-old female with SLE having autoimmune hemolytic anemia, autoimmune thrombocytopenia, renal involvement, and recurrent flares of skin manifestations. She did not respond to the conventional therapy and was controlled and treated with Rituximab, a chimeric, monoclonal antiCD20 antibody, which specifically depletes B lymphocytes