Open AccessGenital ulcerative pyoderma gangrenosum in Behçet′s disease: A case report and review of the literature
Author(s) -
Pınar Özuğuz,
Seval Doğruk Kaçar,
Vildan Manav,
Şemsettin Karaca,
Fatma Aktepe,
Sena Ulu
Publication year - 2015
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.147866
Subject(s) - medicine , pyoderma gangrenosum , pathergy , sex organ , behcet's disease , dermatology , exacerbation , differential diagnosis , biopsy , skin biopsy , behcet disease , skin ulcer , pathology , disease , biology , genetics
Behçet′s disease (BD), first described by Hulusi Behcet, is a multisystemic disease characterized by recurrent oral and genital ulcerations, ocular and cutaneous lesions, arthritis and vascular disease. Pyoderma gangrenosum (PG) is a rare, chronic, sterile pustular and progressive ulcerative process of unknown cause; sometimes can participate in the differential diagnosis of Behcet′s ulceration. A 33-year-old woman complained a severe genital ulcer. She had a purulent oozing and stinky ulceration on the right side of labium minor measuring 5-8 cm. A punch biopsy at ulcer margin showed that the lymphocytic panniculitis was extending to the subcutaneous fat tissue without fibrin deposition or necrotic changes in the vessel wall. Based on the clinical and histological findings, she was diagnosed as genital ulcerative PG, which occurred during the exacerbation of BD