Open AccessMultiple hamartoma syndrome: Clinicoradiological evaluation and histopathological correlation with brief review of literature
Author(s) -
Emma Monga,
Prashant Gupta,
Avinash Munshi,
Shikha Agarwal
Publication year - 2014
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.143535
Subject(s) - medicine , mucocutaneous zone , cowden syndrome , dermatology , hamartoma , malignancy , pathology , gastrointestinal tract , disease , pten , apoptosis , biochemistry , chemistry , pi3k/akt/mtor pathway
Cowden syndrome (CS) or multiple hamartoma syndromes (MHSs) is an uncommon condition and characterized by mucocutaneous lesions which may be associated with the lesions of breast, thyroid, gastrointestinal tract, skin, and often of central nervous system. A thorough evaluation of Cowden's disease is essential due to increased risk of malignancy in an organ or system of the affected patients. We are reporting a case of female patient who presented with multiple mucocutaneous papilloma associated with involvement of multiple organs and systems. The diagnosis was confirmed by multimodality diagnostic approach. This rare entity has not being reviewed in Indian literature till date. Being a rare case, we are discussing MHS with its clinicoradiological and histopathological correlation along with brief review of literature.