Open AccessApoptosis and clinical severity in patients with psoriasis and HCV infection
Author(s) -
Sami A. Gabr,
Mohamed A Berika,
Ahmad H. Alghadir
Publication year - 2014
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.131377
Subject(s) - psoriasis , medicine , pathogenesis , immunology , hepatitis c virus , antibody , immune system , disease , psoriasis area and severity index , severity of illness , gastroenterology , virus
It has been proposed that hepatitis C virus (HCV) antigens are involved in the pathogenesis of psoriasis and may contribute to severity of the disease. Increased expression of the apoptosis-regulating proteins p53 and tTG and decreased levels of bcl-2 in the keratinocytes of the skin of psoriatic patients have been reported.