Open AccessRole of histamine as a toxic mediator in the pathogenesis of vitiligo
Author(s) -
S K Panja,
Biman Bhattacharya,
Sitesh Chandra Lahiri
Publication year - 2013
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.119947
Subject(s) - vitiligo , medicine , mediator , pathogenesis , histamine , dermatology , immunology , pharmacology
The precise cause of vitiligo is still unclear. Multiple theories have been proposed, including genetic, autoimmune, neural, and biochemical mechanisms. An immune mediated pathogenesis is indeed the most popular theory. The autoimmune hypothesis considers the role of toxic mediator that might cause an injury to the melanocytes with the release of an antigenic substance and subsequent autoimmunization.