Open AccessMultiple familial trichoepithelioma with malignant transformation
Author(s) -
Rehab Monir Samaka,
Ola Ahmed Bakry,
Iman Seleit,
Moshira Abdelwahed,
Rania Hassan
Publication year - 2013
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.117348
Subject(s) - trichoepithelioma , medicine , malignant transformation , basal cell carcinoma , pathology , differential diagnosis , basal cell , dermatology
Trichoepithelioma (TE) is a benign tumor of follicular origin that presents as small, skin-colored papules predominantly on the face. When more than one family member is affected, the disease is known as multiple familial trichoepithelioma (MFT). It is a rare autosomal dominant (AD) skin disease. Malignant transformation is very rare. We present a case of MFT in a female patient and her father with malignant transformation to basal cell carcinoma (BCC) in the father. We summarized the main histological differential parameters between TE and BCC and applied immunophenotyping for both by administration of Bcl2, CD34, CD10 and androgen receptor (AR) antibodies