Open AccessKojic acid vis-a-vis its combinations with hydroquinone and betamethasone valerate in melasma: A randomized, single blind, comparative study of efficacy and safety
Author(s) -
Kirti Deo,
Kedarnath Dash,
Yugal K Sharma,
Neha C Virmani,
Chetan Oberai
Publication year - 2013
Publication title -
indian journal of dermatology/indian journal of dermatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.395
H-Index - 36
eISSN - 1998-3611
pISSN - 0019-5154
DOI - 10.4103/0019-5154.113940
Subject(s) - kojic acid , melasma , medicine , dermatology , tolerability , randomization , randomized controlled trial , hydroquinone , betamethasone , pharmacology , adverse effect , tyrosinase , chemistry , organic chemistry , enzyme
Melasma is a relatively common, acquired symmetric hypermelanosis characterized by irregular light to gray-brown macules involving sun-exposed areas. Kojic acid, with its depigmenting potential due to tyrosinase inhibition and suppression of melanogenesis, has become a vital component of the dermatologists' armamentarium against melasma.