Open AccessEffect of tranexamic acid on blood loss and transfusion requirement in total knee replacement in the Indian population: A case series
Author(s) -
Parshotam Lal Gautam,
Sunil Katyal,
Mohammad Yamin,
Anupama Singh
Publication year - 2011
Publication title -
indian journal of anaesthesia/indian journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 30
eISSN - 0976-2817
pISSN - 0019-5049
DOI - 10.4103/0019-5049.90614
Subject(s) - tranexamic acid , medicine , tourniquet , anesthesia , fibrinolysis , saline , antifibrinolytic , blood transfusion , surgery , placebo , population , context (archaeology) , blood loss , alternative medicine , environmental health , pathology , paleontology , biology
Total knee replacement (TKR) is often carried out using a tourniquet to minimize intraoperative blood loss. However, its application enhances local fibrinolysis, resulting in excessive blood loss during the post-operative period. Fibrinolytic profile varies in different regions and races. Tranexamic acid has been shown to reduce post-operative blood loss and the need for transfusion in TKR. However, there is paucity of literature from the Indian population and the efficacy of the agent has not been tested in Indian patients undergoing TKR.