Open AccessFulminant hepatic failure after repeated exposure to isoflurane
Author(s) -
Halemani R Kusuma,
N. K. Venkataramana,
Shailesh A. V. Rao,
Arun L Naik,
DS Gangadhara,
Keshavan H Venkatesh
Publication year - 2011
Publication title -
indian journal of anaesthesia/indian journal of anaesthesia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.645
H-Index - 30
eISSN - 0976-2817
pISSN - 0019-5049
DOI - 10.4103/0019-5049.82696
Subject(s) - medicine , fulminant hepatic failure , isoflurane , halothane , fulminant , anesthesia , hepatitis , general anaesthesia , fulminant hepatitis , surgery , liver transplantation , transplantation
Inhalational agents are used routinely for maintenance of anaesthesia. Post anaesthesia hepatic failure has been documented following exposure to halothane. However, there are very few reports of such complications following isoflurane anaesthesia. A 6-year-old child developed fulminant hepatic failure 2 days following craniotomy under general anaesthesia. There was no evidence of viral, autoimmune, or metabolic causes of hepatitis. No other medications known to cause hepatitis, except low dose paracetamol, were administered. The clinical and histological picture of our case is similar to that of halothane hepatitis, which has a significant mortality rate. We report this as a possible fulminant hepatic failure resulting from exposure to isoflurane anaesthesia.